Endocrine Abstracts

Background: Only a few cases of pituitary tumor swift from non-functioning to Cushing disease (CD) have been previously presented in the literature. The exact mechanism is still unknown. We present a case of a patient with a non-functioning pituitary adenoma, who developed CD from the residual tumor, 13 years after the initial diagnosis and following 2 surgical interventions and radiation therapy.Case presentation: A 51-year-old woman initially presented...

Introduction: Radioactive iodine-refractory differentiated thyroid cancer is a rare form of advanced thyroid cancer (approximately 4 cases per million population per year) defined by persistent disease after administration of a cumulative radioiodine dose of 600 mCi or at least one tumor without radioactive iodine uptake or by progression of the disease within one year after RAI treatment. Therapeutic options in this case include molecular-targeted therapies, like tyrosine kin...

Introduction: Neuroendocrine tumours (NETs) of unknown primary site are relatively uncommon, representing about 10% of all NETs. Of these, particularly the well-differentiated NETs often present initially with liver metastases, and most of these represent gastroenteropancreatic NETs. The presence of carcinoid syndrome is also common.Case presentation: We describe the case of a 40 years-old patient presented in 2013 with flushing, diarrhea, and back pain....

Background: Primary hyperaldosteronism or Conn’s syndrome is one of the adrenocortical causes of hypertension, alongside hyperdeoxycorticosteronism, apparent mineralocorticoid excess and Cushing syndrome. The two types of hypertension-inducing adrenocortical syndromes (Conn’s and Cushing) are extremely rare to be decribed in the same patient. We describe a case of a patient with clinical and biochemical evidence of Conn’s syndrome due to a left adrenal adenom...

IntroductionAdjuvant endocrine therapy has an important role in the management of hormone receptor-positive (expressing oestrogen/progesterone receptors) early-stage breast cancer, reducing the risk of recurrence and improving associated mortality. The estradiol depletion produced by hormone therapy has detrimental effects on skeletal health, which can lead to low bone mineral density (BMD), altered bone microarchitecture and increased risk of fracture.<...

BackgroundAcromegaly is a rare disease, caused by an autonomous excessive secretion of growth hormone (GH). Apart from skeletal alterations, the GH excess leads to metabolic and visceral disease. Thus, one of the most frequent associated complications is the cardio-vascular one represented by hypertension, cardiomyopathy and ischemic heart disease. The presence of multiple complications in patients with acromegaly leads not only to increased morbidity an...

Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome, characterized by primary MEN1 tumors: parathyroid, pancreatic and pituitary. We describe the case of a patient with MEN1 syndrome, initially presented with a gastric neuroendocrine tumor (NET).Case presentation: A 33-year-old male patient, initially treated for perforated gastric ulcer, presented 7 years later with dyspepsia, diarrhea and weight loss. Abdominal CT scan revea...